As few examples, this analysis singled out 104 genes that are likely playing a key role in linking risk for T2D and the differentiation of beta cells (Table S4), among them SLC30A8 [36], [37], [38], [39], WFS1 [40] and SLC2A2 (GLUT2) [41] that were previously implicated as T2D risk genes (Fig. 5A). This evidence concerns the gene WFS1 and type 2 diabetes mellitus.