In addition, KMT2D deficiency augments the tumor-inhibitory effect of the curcumin analog L48H37 on pancreatic cancer cells [85] and increases the sensitivity of other cancer cells to chemotherapeutic drugs, such as doxorubicin, carboplatin, and the nucleotide analog Fluorouracil [46, 86]. Here, KMT2D is linked to familial pancreatic carcinoma.