KMT2D and lung carcinoma: Consistent with our finding that Kmt2d loss increases glycolysis in lung tumorigenesis, [32], we showed that pharmacological inhibition of glycolysis using 2-deoxy-D-glucose impeded the proliferation of human lung cancer cell lines bearing KMT2D truncations to a greater extent than that of KMT2D-WT lung cancer cell lines and selectively inhibited the tumorigenicity of KMT2D-deficient lung cancer cells in mice [32].