Anti-LAT1 mAb reacted with non-fixed living HEK293 and SW1116 colon cancer cells, whose CD98hc gene was almost completely disrupted by the CRISPR/Cas9-based KO (Figure 6D), suggesting that disulfide binding with CD98hc is not necessarily required for the cell-surface expression of LAT1. Here, SLC3A2 is linked to malignant colon neoplasm.