It has been well established that CaMKII plays a prominent role in myocardial hypertrophy, pressure overload-induced cardiac hypertrophy and fibrosis, ischemia/reperfusion (I/R) injury, heart failure (HF), postmyocardial infarction (MI) remodeling, and ventricular arrhythmias [15, 17–21]. Here, CAMK2G is linked to cardiac hypertrophy.