INSR and diabetes mellitus: Of the two major types of DM, type 2 DM (T2DM) is more common and accounts for around 90% of all diabetes cases worldwide [4] and has been managed through restoration of endogenous production of insulin, improving the sensitivity of insulin receptors, administration of oral antidiabetic drugs, and delaying glucose release from dietary starch by carbohydrate-degrading enzymes such as α-amylase (E.C. 3.2.1.1) and α-glucosidase (E.C. 3.2.1.20) [5, 6].