Cho et al. [119] have reported that targeted activation of IL-1β transcription by microglia SIRT1 deletion is probably modulated by hypomethylation of specific CpG sites within the proximal promoter of IL-1β, resulting in cognitive deficits in two separate models of aging, indicating that altered methylation of IL-1β may be associated with cognition. This evidence concerns the gene IL1B and Cognitive impairment.