KDM6B and Parkinson disease: Tang et al. [144] have disclosed reduced levels of Jmjd3, along with the elevated expression of H3K27me3 and higher ratios of microglia M1/M2 in aged mice, suggesting that upregulation of the Jmjd3 level may be able to facilitate the polarization of M2 phenotype by modifying H3K27me3, which may be an effective therapeutic method for the treatment of PD.