In summary, the RhoGDI canonical pathway also in conjunction with other Rho- related and Ephrin- related signaling cascades as well as with the Axonal Guidance Signaling pathway might be involved in controlling the differential resistance to nematode infection in sheep and possibly, all of these processes may be modulated by co-expressed lncRNAs. The gene discussed is ARHGDIA; the disease is Nematoda infectious disease.