For example, by analyzing differential mRNAs, Sun et al. have found that S100A16, IGKV4, S100P, ANGPTL4, SEMA4B, and LGR4 are high-risk immune genes in NSCLC that affect the prognosis of the disease (Sun et al., 2020). The gene discussed is LGR4; the disease is non-small cell lung carcinoma.