The number of CYP2C9 deficient alleles increased the odds of hypoglycemia nearly 3-fold (OR, 2.81; 95% CI, 1.30-6.09; P = 0.009) only at the POR*1/*1 genotype background  Statistically significant interaction between POR and CYP2C9 genotypes (P = 0.007). This evidence concerns the gene CYP2C9 and Hypoglycemia.