CYP2C9 and Hypoglycemia: POR*28 allele was not associated with severe hypoglycemia. CYP2C9 *2 allele increased the risk of hypoglycemia by more than 3 times (OR: 3.218, p = 0.031).  POR*28 allele is masking the association of CYP2C9*2 allele with severe hypoglycemia.