ABCC8 and Hypoglycemia: Three other studies investigated association between two strongly linked non-synonymous polymorphisms, S1369A (rs757110) and E23K (rs5219), in the ABCC8 and KCNJ11 genes, respectively with hypoglycemia (Sato et al., 2010; Holstein et al., 2012; Ragia et al., 2012).