In the present study, LASSO Cox regression analysis helped select the eight HRGs (ENO1, GPC3, JMJD6, PGM1, PYGM, SERPINE1, SLC2A1, and STC2) from a total of 77 genes to develop the hypoxia gene signature, which was an independent prognostic factor for HCC patients (Table 2). This evidence concerns the gene PYGM and hepatocellular carcinoma.