The genes WARS and TPH1, and KP genes AFMID, HAAO, and KYAT1/CCBL1 were shown to have a significant burden of qualifying rare protein-altering variants in sporadic ALS compared to the non-neuronal Non-Finnish European subset of the gnomAD dataset (Table 1), although this was not replicated when compared to Australian controls. Here, TPH1 is linked to amyotrophic lateral sclerosis.