IL4 and non-small cell lung carcinoma: Lastly, we found that IL-4 and IL-13 were highly expressed in PD-1high ILC2s in terms of both mRNA and protein levels, indicating that PD-1high ILC2s may enhance the type 2 immune response by upregulating IL-4 and IL-13 and act as immunosuppressive cells in human NSCLC.