TGFB1 and renal fibrosis: To investigate the role of macrophages, AIM, TGF-β1 in the progression of IgAN fibrosis, we detected infiltration of macrophages in renal tissues of IgAN patients and the expression level and characteristics of AIM and TGF-β1, and then analyzed the relationship among the three and clinical related indicators and renal fibrosis area of IgAN patients.