All the three were closely related to 24-hour urinary protein, serum creatinine, eGFR and other clinical indicators of IgAN patients, and there was a significant positive correlation between the three and the area of renal fibrosis, which indicate that M2 macrophages, AIM and TGF-β1 were all involved in the occurrence and development of IgAN and were closely related to the fibrosis process of IgAN. This evidence concerns the gene CD5L and renal fibrosis.