Previous studies have observed that mRNA and protein expression of TGF-β1 in IgAN and the infiltration degree of M2 macrophages in renal tissue were significantly increased compared with normal renal tissue (31), TGF-β1 was co-expressed with M2 macrophages in renal biopsy tissue of CKD induced hypertension. The gene discussed is TGFB1; the disease is chronic kidney disease.