ACE2 and hypertensive disorder: The medical management of hypertension involves the use of RAAS inhibitors, such as angiotensin converting enzyme inhibitors (ACEis) and Ang II Receptor Blockers (ARBs), considered to up-regulate the cell surface expression of ACE2, with the possible adverse effects of increasing the susceptibility to SARS-CoV-2 of patients who receive these treatments (76, 77).