CCNE1 and hepatocellular carcinoma: Insertion in TERT promoter, CCNE1 (cyclin E1), CCNA2, MLL4 (Myeloid/lymphoid or mixed-lineage leukemia 4), TP53, and CTNNB1 have been repeatedly detected in HCC (Paterlini-Brechot et al., 2003; Sung et al., 2012; Kawai-Kitahata et al., 2016), but these are not present in all tumors.