CD274 is expressed by other immune cells in greater a proportion than that of PDCD1LG2 expression (58)⁠, which may help explain why the dispersion seen in scatter plots was more evident for CD274. In addition, patients with HSP ACC overall presented lower levels of CD8B and CD274/PDCD1LG2 expression compared to those of patients with LSP ACC. Here, CD274 is linked to hereditary spastic paraplegia.