Among driver genes, the most common mutations found in the ACC cohort were in TP53 (n = 16), CTNNB1 (n = 13), and MEN1 (n = 7); however, these mutations were mainly present in patients with HSP (n = 13 of 16, n = 13 of 13, and n = 6 of 7, respectively). The gene discussed is TP53; the disease is hereditary spastic paraplegia.