In contrast to CD276 (B7-H3) and FLT1 (VEGFR1), BTLA, interleukin 10 (IL10), IL10 receptor subunit alpha (IL10RA), integrin beta chain-2 (ITGB2), CD274 (PD-L1), and PDCD1LG2 (PD-L2) are significantly downregulated in HSP (Supplementary Table 1, Figures 6A and 7B). This evidence concerns the gene ITGB2 and hereditary spastic paraplegia.