Interestingly, the two direct connectors to the candidate genes, XPO1 and EED, themselves present plausible functions related to the phenotype, XPO1 being a cell cycle-regulated gene and EED, mediating suppression of gene activity through histone deacetylation, and being causative for an overgrowth syndrome similar to Weaver syndrome (20, 21). Here, XPO1 is linked to overgrowth syndrome.