Interestingly, the two direct connectors to the candidate genes, XPO1 and EED, themselves present plausible functions related to the phenotype, XPO1 being a cell cycle-regulated gene and EED, mediating suppression of gene activity through histone deacetylation, and being causative for an overgrowth syndrome similar to Weaver syndrome (20, 21). The gene discussed is EED; the disease is Weaver syndrome.