A specific subset of miRNAs that downregulate CMA has also been identified (203), and treatment with Geniposide, a bioactive iridoid glycoside that acts as a down-regulator of miRNAs especially for miR-21, increased LAMP2A expression and reduced α-synuclein levels in SH-SY5Y cells and MPTP-treated PD model mice (204). Here, SNCA is linked to Parkinson disease.