Moreover, a correlation was observed between CSF pTDP-43 levels and the ALSFRS-R (r = −0.245, P = 0.042) (Figure 3B); Moreover, the correlation between plasma and CSF TDP-43 was observed in each ALS patient (r = 0.195, P = 0.027), however, no correlation was found between plasma or CSF pTDP-43 levels and other clinical indicators (Supplementary Material 2). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.