Depending on the genetic variability, the APOE gene has been ascribed significant positive and negative health effects such as longevity and shortened lifespan, neurological and psychosomatic disorders, cognitive decline and Alzheimer disease, altered lipoprotein profile, atherosclerosis and cardiovascular disease, type II diabetes, changes in the immune response, oxidative stress, quality of life, physical activity, and obesity (Spinney, 2014; Klimentidis et al., 2018; Abondio et al., 2019; Kulminski et al., 2019). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.