ADRB2 and hepatocellular carcinoma: In addition, in another study, autophagic regulation by ADRB2 is assessed by immunoblotting, immunofluorescence and immunoprecipitation assays, demonstrating that ADRB2 signaling negatively regulates autophagy by disrupting the Beclin1/VPS34/Atg14 complex in an Akt-dependent manner, reprogramming HCC cells glucose metabolism (Wu et al., 2016).