IGHE and allergic disease: Given the clinical application of Forsythiae Fructus for the treatment of allergic diseases (Chien et al., 2013; Chen et al., 2015a), together with the fact that Shuang-Huang-Lian Injection containing Forsythiae Fructus markedly prevented IgE/FcεRI-mediated MC degranulation (Gao et al., 2017), it is very likely that Forsythiae Fructus can also dampen IgE/FcεRI-mediated MC degranulation.