Modified Dioscorea Pills (MDP) promotes the regeneration and repair of hippocampal neurons by inhibiting downregulation of the ERK5/BMK1 signaling pathway, improving disorder in the hippocampal tissue structure in VD model rats, and reducing apoptosis in hippocampal neurons, thereby improving learning ability and memory (Li et al., 2020b). This evidence concerns the gene MAPK7 and sexually transmitted disease.