CASP3 and sexually transmitted disease: Zhao et al. demonstrated the ratio of Bax to Bcl-2 and the cleaved caspase-3 expression were significantly higher in VD rats than those in control groups, suggesting that severe apoptosis occurred via the mitochondria-related Bax/Bcl-2 and caspase-3 pathway in the progression of chronic cerebral hypoperfusion to VD (Zhao et al., 2018).