Yang et al. found that JYF decreases the neuron apoptosis rate and Bax levels, increases Bcl-2 levels, and decreases the Bcl-2/Bax ratio in the SAMP 8 brain, which is probably part of the mechanism of inhibiting apoptosis and improving cognitive function (Yang et al., 2006), suggesting anti-neuronal apoptosis is also a promising therapeutic target for VD. The gene discussed is BCL2; the disease is sexually transmitted disease.