Over the past two decades, many studied have indicated that IL-1β, IL-6, and TNF-α are closely implicated in cardiac fibrosis, pathological cardiac remodeling, and cardiac hypertrophy (Sun et al., 2007; Coles et al., 2007; Cannon, 2000; Melendez et al., 2010). Here, IL1B is linked to cardiac hypertrophy.