EDN1 and cardiovascular disorder: We are concerned that the levels of uric acid, hypoxanthine and ET-1 are higher in Xu-subtype CHD than those in control group and Shi subtype group, and ATP is significantly reduced in the Xu-subtype CHD, which means that in addition to aggravating vascular endothelial damage, also promote the formation of foam cells, which is more likely to lead to cardiovascular disease.