Our previous research demonstrated that GBFXD could modulate the microbiota-acetate-regulatory T cell (Treg) axis (Dong et al., 2020), downregulate the asthma susceptibility gene ORMDL3 (Huang et al., 2016), and suppress endoplasmic reticulum (ER) stress responses (Lu et al., 2016) in a murine model of chronic remission asthma (CRA). The gene discussed is ORMDL3; the disease is asthma.