According to KEGG pathway enrichment analysis, the DEPs from the model/control and GBFXD/model groups were shown to be simultaneously involved in ECM-receptor interactions, the PI3K/AKT signaling pathway, and focal adhesion, which were the top three significantly enriched pathways (Figures 5E,F) and have been reported to participate in airway remodeling in asthma (Athari, 2019; Yap et al., 2019; Zhou et al., 2019; Ali et al., 2020). The gene discussed is AKT1; the disease is asthma.