SORBS1 and Alzheimer disease: For example, IFITM3 is a reliable biomarker of the inflammatory microglial phenotype in AD damaged tissues (Correani et al., 2017), and the expression of SORBS1 is higher, while the expression of ENSA is lower in the brain of patients with AD (Blalock et al., 2004; Boettcher et al., 2008).