For example, in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), changes in the localization of transactive responsive-DNA binding protein 43 (TDP-43) (Arai et al., 2006; Neumann et al., 2006) and fused in sarcoma (FUS) (Kwiatkowski et al., 2009; Vance et al., 2009), as well as formation of inclusion bodies containing these proteins are seen in neurons. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.