Briese et al. (2020) showed that mRNAs of translation-related proteins including ribosomal proteins are identified as targets for TDP-43-dependent axonal transport in motor neurons, and TDP-43 regulates their local translation. Other reports also showed that mice overexpressing TDP-43 localized in the cytoplasm or mutant FUS have a decrease in overall protein translation in neurons including axons, postulating their involvement in the pathogenesis of ALS/FTD (López-Erauskin et al., 2018; Charif et al., 2020). Here, TARDBP is linked to frontotemporal dementia.