Alzheimer’s disease is a clinical syndrome characterized by brain amyloid-beta (Aβ) protein deposition in senile plaques (SPs), downstream neuronal degeneration, and tau protein hyperphosphorylation (p-tau) forming neurofibrillary tangles (NFTs) (McKhann et al., 2011). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.