MAPT and Alzheimer disease: Thus, further studies are warranted to assess the effect of NX210c on amyloid plaque deposition and neuronal death by using other AD models such as the APP/PS1 mouse model (Jankowsky et al., 2004), the 3 × Tg-AD mouse model with mutations in APP, PS1, and tau genes (Oddo et al., 2003), and the 5 × familial AD mouse model with five mutations in APP and PS1 genes (Oakley et al., 2006).