We examined the protein levels of key pathological hallmarks of AD in the hippocampi and prefrontal cortices of control and Aβ25–35-injected mice treated or not with NX210 or NX210c (2 mg/kg), or donepezil (1 mg/kg) for 11 days, using ELISA for Aβ1–42, pTau, TNF-α, GFAP, caspase-12, synaptophysin and PSD95, and the measure of CHP absorbance for LPO. This evidence concerns the gene CASP12 and Alzheimer disease.