PSEN1 and Alzheimer disease: This is in line with increased protein levels of β1-integrin, NOX2 and GFAP in hippocampal astrocytes of 18-month-old triple-transgenic (3 × Tg)-AD mice with mutations in APP, PS1 and tau and in postmortem prefrontal cortices of patients with AD (Wyssenbach et al., 2016).