Further subtype analysis found that the highest accuracy for diagnosing high-grade IDH-wild type (IDH-wt) FET-positive glioma was using DWI combined with FET PET (AUC 0.89), and for FET-negative gliomas, the DWI parameters had the highest diagnostic accuracy (AUC 1.00). This evidence concerns the gene IDH1 and central nervous system cancer.