CD33 and acute myeloid leukemia: When comparing CD33+ AML and CD33+ PB, the top discriminating 30 biochemicals included lipids, nucleotides, and amino acid metabolism (Fig. 2E), with alanine, aspartate and glutamate, cysteine and methionine, purine and sphingolipid metabolic pathways showing the strongest impact (Fig. 2F and Table S8).