When comparing TP53-mut/del and wild-type (wt) AML, we found lower levels of threonine and glucose in TP53-mut/del cases (Fig. 1I), that suggested an increased cellular uptake, likely aimed at satisfying macromolecule biosynthesis and bioenergetic requirements [32], with reduced lactate excretion [33]. Here, TP53 is linked to acute myeloid leukemia.