Compared with NPM1-mut AML, NPM1/cohesin-mut cases were characterized by a lower white blood cell count (39.7 vs. 64.1 cells/mm3, p = 0.006) and a significantly higher mutation load (average mutation number: 15 vs. 9, p < 0.001), with lower frequency of IDH1–2/TET2 mutations (21.9% vs. 46.7% of NPM1-mut, p = 0.014, Fig. 6B). Here, NPM1 is linked to acute myeloid leukemia.