Seven downregulated genes in NPM1/cohesin-mut compared with NPM1-mut AML encoded for enzymes involved in nucleotide (ADCY9, DPYSL2), lipid (LPL) and carbohydrate (CHST13) metabolism, energy production (CYP1B1) and transporter/exchanger (SLC8A1, SLC1A3, Figs. 7C and S6B). The gene discussed is ADCY9; the disease is acute myeloid leukemia.