Figure 3 illustrates the protein structures of PI3K and the p85 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α complex (PDB ID: 5DXU)73; 14 amino acids, including one neutral and 13 cancer-related SAVs, are drawn as spheres. This evidence concerns the gene PIK3CD and cancer.