The ethyl [5-hydroxy-1-(6-methoxy-4-methyl-3-quinolinyl)-3-methyl-1H-pyrazol-4-yl]acetate (FC = 1.24, p value = 0.04), cyclobutylamine (FC = 0.74, p value = 0.01), butanoic acid, (tetrahydro-2-furanyl)methyl ester (FC = 0.72, p value = 0.01), hexane, 2,3,5-trimethyl- (FC = 0.70, p value = 0.02), 1H-Tetrazole-1-ethanol (FC = 0.78, p value = 0.04), cyclopropene (FC = 0.74, p value = 0.04), 4H-1,2,4-Triazol-4-amine (FC = 0.75, p value = 0.045), and allyl acetate (FC = 0.75, p value = 0.046) were significantly decreased in the lung cancer subjects without EGFR mutation. The gene discussed is EGFR; the disease is lung carcinoma.