CD8A and infection: To test this, we infected mice with ZIKVCDN or ZIKVBR and determined the impact of treating ZIKVBR-infected mice on days 2 and 3 post-infection with the toll-like receptor (TLR)−3 agonist polyinosinic:polycytidylic acid (pI:C) or murine rIFN-β on the CD8αloCD11ahi CD8 T cell response 7 dpi.