FOS and cancer: We detected several deregulated transcripts among cancer-related genes, either activated oncogenes (MYC, AKT2, FOS, BCL11A, EGFR among others) or downregulated oncosuppressors (BRCA2, CDKN2C) (Fig. 4e, f and Supplementary Fig. 4f) further strengthening the possibility that mutant progenitors were deeply transformed when compared to the wild-type.