Beyond SETBP1 this group includes ASXL1 (myeloid malignancies and Bohring–Opitz syndrome), EZH2 (B-cell lymphoma and Weaver syndrome) as well as several genes of the MAP kinase pathway, FGFR2, FGFR3, HRAS, PTPN11, BRAF, MAP2K1 (many types of cancers and paternal age–effect disorders such as Noonan syndrome and others)61. The gene discussed is PTPN11; the disease is cancer.