To study the pathological effects of SGS-causing SETBP1 mutations in a human in vitro model, we reprogrammed fibroblasts obtained from two SGS patients and two age-matched controls (WT1 and WT2) into iPSCs through the Sendai virus nonintegrant method (Fig. 1a). The gene discussed is SETBP1; the disease is Schinzel-Giedion syndrome.