For example, BACE1-AS transcript, which is significantly up-regulated in the brains of Alzheimer's disease patients, base-pairs with beta-secretase-1 (BACE1) mRNA, stabilizing it (Faghihi et al. 2010), whereas BC200 represses translation initiation in dendrites by disrupting the formation of preinitiation 48S complexes (Wang et al. 2002). Here, BACE1 is linked to early-onset autosomal dominant Alzheimer disease.