BACE1 and Alzheimer disease: For example, BACE1-AS transcript, which is significantly up-regulated in the brains of Alzheimer's disease patients, base-pairs with beta-secretase-1 (BACE1) mRNA, stabilizing it (Faghihi et al. 2010), whereas BC200 represses translation initiation in dendrites by disrupting the formation of preinitiation 48S complexes (Wang et al. 2002).