Similar to STAG3 in which clinical evidence associating its mutation to ovarian dysfunction is limited to case studies, helicase for meiosis 1 (HFM1), nucleoporin 107 (NUP107) and synaptonemal complex central element protein 1 (SYCE1) were identified as candidate genes in DNA repair that are implicated in ovarian insufficiency [13, 61–63]. Here, HFM1 is linked to ovarian dysfunction.