The integrated diagnoses, based on histology, sequencing and DNA-methylation patterns were pilocytic astrocytoma (n = 8 patients), glioblastoma, IDH wildtype (n = 6 patients), diffuse midline glioma, H3 K27M mutated (n = 5 patients), high-grade astrocytoma with piloid features (n = 4 patients), diffuse astrocytoma, IDH mutated (n = 2 patients) and diffuse leptomeningeal glioneuronal tumor (n = 1 patients). Here, IDH2 is linked to diffuse midline glioma.