For instance, the tumor of youngest patient (case #22) had a NTRK1 fusion gene, which is typical for a subgroup of infant hemispheric gliomas with receptor-tyrosine kinase activation, yet the current methylome classifier (v11b4) produced a high calibrated score (0.99) for the methylation class “glioblastoma, IDH wildtype, subclass midline” [14]. This evidence concerns the gene IDH2 and central nervous system cancer.