GSTM1 and hypertensive disorder: We hypothesis that the GSTM1/GSTT1 active variants with normal detoxification activity, could reduce the bioavailability of antihypertensive drugs and by doing so, GSTM1/GSTT1 deletion polymorphisms, in addition to their association with the risk of developing essential hypertension, could modulate the response to antihypertensive treatments, therefore the control of BP.