As mentioned, serine phosphorylation of STATs may affect transcriptional control and the methylation of STAT3 by Enhancer of Zeste 2 (EZH2) identified as a mediator of transcriptional control in other solid tumours requires investigation in MPN to fully understand the dynamics at play between STAT proteins and final phenotypes [63, 68, 71]. This evidence concerns the gene STAT3 and myeloproliferative neoplasm.