Activated MAPK, PI3K/AKT and JAK/STAT signalling are also observed in numerous myeloid malignant phenotypes including acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), atypical CML, chronic myelomonocytic leukaemia and juvenile myelomonocytic leukaemia [77]. Here, AKT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.