PARP1 and malignant colon neoplasm: Furthermore, we observed that and Bcl-xL levels increased, whereas Bcl-xS and cleaved PARP1 levels decreased, in SRPK1-overexpressing colon cancer cells (Fig. 3d, Additional file 3: Fig. S2b, c), and the opposite effect was observed in SRPK1 knockdown cell lines (Fig. 3d, Additional file 3: Fig. S2b, c).