SRPK1 and malignant colon neoplasm: By analyzing the expression of SRPK1 in the Cancer Genome Atlas (TCGA) database, we found that the SRPK1 mRNA expression was the second highest in colon cancer, which was only lower than that in rectum adenocarcinoma (READ) among 33 types of cancer, and the SRPK1 mRNA expression was increased in the TCGA colon cancer tissues (n = 286) compared with that in normal tissues (n = 41) (p < 0.001) (Fig. 1a, b).