Thus, we used the TCGA 450 k array to perform independent prognostic analysis of TCGA CRC methylation sites and determined that 64 RBPs with prognostic methylation sites (Additional file 5) included 10 differentially expressed RBP genes (RPL37, NOL10, CD3EAP, EIF5A, OASL, NHP2, RRS1, NUFIP1, RRP12 and EIF4E). This evidence concerns the gene EIF4E and colorectal carcinoma.