We found that, in addition to interacting with CD2, CD58 was co-expressed and physically interacted with HOXB family genes (HOXB2, HOXB3, and HOXB5), AKAP12, CLIC1, CPNE3, etc., which were reported to be involved in tumor initiation and progression [42–45]. Here, CPNE3 is linked to neoplasm.