CD58 and neoplasm: Furthermore, CD58 expression was positively associated with histological grade (p = 0.015) and tumor size (p = 0.020), namely the higher the pathological grade and the larger the tumor, the higher the expression of CD58 (Table 1 and Fig. 4d, e), but no significant correlation was detected between CD58 expression and other clinicopathological parameters, including age, gender, tumor location, lymph node metastasis, TNM stage, perineural invasion, and macrovascular invasion.