Furthermore, the KEGG pathway analysis to explore CD58-related signaling pathways indicated the pathways in cancer, tight junction, axon guidance, adherens junction, proteoglycans in cancer, focal adhesion, pancreatic cancer, ECM-receptor interaction, and leukocyte transendothelial migration, as well as regulation of actin cytoskeleton (Fig. 6f). This evidence concerns the gene CD58 and cancer.