The second group is adrenal hypoplasia, including X-linked adrenal hypoplasia congenita (AHC) caused by NR0B1 [6], adrenal hypoplasia caused by steroidogenic factor-1/NR5A1 [6], IMAGe syndrome caused by CDKN1C [7] and MIRAGE syndrome caused by SAMD9 [8]. This evidence concerns the gene NR0B1 and chronic primary adrenal insufficiency.