Adrenal destruction constitutes another group, consisting of Allgrove syndrome caused by AAAS [11], nicotinamide nucleotide transhydrogenase deficiency caused by NNT [12]and thioredoxin reductase deficiency caused by TXNRD2 [13]. The gene discussed is TXNRD2; the disease is hyperinsulinemic hypoglycemia, familial, 4.