Compared to lower proliferative cells MCF7 and T47D, highly proliferative breast cancer cells MDA-MB-231, BT549 and SUM159 expressed high levels of FMNL2 along with high proliferative features including enhanced Ki67 and CyclinD1 levels, and reduced levels of p27 and p21 (Fig. 1c). This evidence concerns the gene CCND1 and breast carcinoma.