FMO5 and endothelial dysfunction: In animal studies, diabetic rats which were treated by SGLT2 inhibitor had a lower development of endothelial dysfunction, oxidative stress, advanced glycation end products/ receptor for advanced glycation end products (AGE/RAGE) signaling and inflammation due to inhibition of the activity of NADPH oxidase and decreased serum levels of the AGE precursor methylglyoxal [24].