SOD1 and type 1 diabetes mellitus: Previous human studies have shown that concomitant treatment with empagliflozin and metformin in patients with type 1 diabetes reduced IL-6 up to 1.34 fold and improved anti-oxidative status parameters comprising of total anti-oxidative status (TAS) for up to 1.07 fold and superoxide dismutase (SOD) for up to 1.08 fold.