TGFB1 and breast carcinoma: For instance, KIF3C expression level is increased in breast cancer, and high KIF3C expression is associated with lymph node metastasis and tumor recurrence; additionally, KIF3C knockdown inhibits the EMT process via suppressing the TGF-β signal pathway and inhibits BC cell proliferation by inducing G2/M phase arrest, which suggests that KIF3C can serve as a biomarker and target for the diagnosis and therapy of breast cancer [13].