To understand the potential clinical relevance of these findings, we assessed the hepatic mRNA expression of GABA transporters (SLC6A6, encodes for TauT; SLC6A8, encodes for the CRT; SLC6A12, encodes for BGT1; and SLC6A13, encodes for GAT2) in 19 people with obesity (age 45 ± 3 years, 2 men and 17 women) who were carefully characterized by measuring intrahepatic triglyceride (IHTG) content using magnetic resonance imaging (MRI) and insulin sensitivity using the hyperinsulinemic-euglycemic clamp procedure (HECP) in conjunction with stable isotopically labeled glucose tracer infusion. Here, SLC6A12 is linked to obesity due to melanocortin 4 receptor deficiency.