In COVID-19 pathology, a functional NK response is associated with enhanced SARS-CoV-2 neutralization by antibody-dependent cellular cytotoxicity (ADCC) [49], increased numbers of the cytokine-producing Cluster of Differentiation (CD)56brightCD16- NK cell subset and upregulated IFN- and XCL2-related genes [50]. Here, IFNA1 is linked to COVID-19.